HPV16 E6

Accession: H001781

Uniprot: C0KXL5

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
CTELQTTIHD ILECVYCKQ LLRREVYDF FRDLCIVYR GNPYAVCDK LKFYSKISE
         .         .         .         .         .         .
YRYYCYSVYG TLEQQYNKP CDLLIRCIN QKPLCPEEK RHLDKKQRC NIRGRWTGR
         .                                                  
CMSCSRSSRT RETQL    

Epitope&Mutation

>H001781_E6
CTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRYYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRCHNIRGRWTGRCMSCSRSSRTRRETQL
··ELQTTIHDIILECVY(A2)···················································································································
···LQTTIHDII(A*0201)····················································································································
······TIHDIILECV(A*0201)················································································································
······TIHDIILEC(B*4801)·················································································································
········HDIILECV(B*4002)················································································································
··········IILECVYCK(A11)················································································································
··············CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
··················KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
··························VYDFAFRDL(A*2402)·····························································································
·····························FAFRDLCIVY(B35)····························································································
·····························FAFRDLCIVY(B57)····························································································
·····························FAFRDLCIV(A*0201)··························································································
·····························FAFRDLCIV(A2)······························································································
····································IVYRDGNPY(A3)·······················································································
····································IVYRDGNPY(A11)······················································································
······································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
······································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
···········································PYAVCDKCL(A*2402)············································································
·············································AVCDKCLK(A11)··············································································
················································DKCLKFYS(A24)···········································································
····················································KFYSKISEY(A24)······································································
····················································KFYSKISEY(B62)······································································
····································································YGTTLEQQYN(A24)·····················································
····································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·····································································GTTLEQQYNK(A11)····················································
······································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
······································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
······································································TTLEQQYNK(A3)·····················································
······································································TTLEQQYNK(A11)····················································
···········································································QYNKPLCDLL(A24)··············································
···········································································QYNKPLCDL(A*2402)············································
··············································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
···············································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
···················································································LLIRCINCQK(A11)······································
···················································································LLIRCINCQK(A3)·······································
···················································································LLIRCINCQK(A11)······································
··············································································································HNIRGRWTGR(A*6801)········
··················································································································GRWTGRCMSC(B27)·······
·····························································································································SSRTRRETQL(B14)