HPV16 E7

Accession: H001757

Uniprot: J9Q2I8

Protein: E7

Organism: Human papillomavirus type 16

Function

E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.

Sequence&Mutation

         .         .         .         .         .         .
MHGDTPTLHK MLDLQPETT LYCYEQLND SEEEDEIDG AGQAEPDRA YNIVTFYCK
         .         .         .                              
CDSTLRLCVQ THVDIRTLE LLMSTLGIV P  

Epitope&Mutation

>H001757_E7
MHGDTPTLHKYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFYCKCDSTLRLCVQSTHVDIRTLEDLLMSTLGIVCP
··········YMLDLQPET(A*0201)·································································
··········YMLDLQPETT(A*0201)································································
··········YMLDLQPETT(A*0201)································································
···········MLDLQPETT(A*0201)································································
···········MLDLQPETT(A2)····································································
················PETTDLYCYEQLNDSSEEEDEI(MHC II)··············································
·················ETTDLYCYE(A1)······························································
····················DLYCYEQLNDSSEEEDEIDGPA(DR4)·············································
··································EDEIDGPAGQAEPDRA(DQ2)·····································
···········································QAEPDRAHY(B18)···································
················································RAHYNIVTF(A*0201)···························
················································RAHYNIVTF(A24)······························
····························································CDSTLRLCVQSTHVDIRTLE(DRB1*0901)·
····························································CDSTLRLCV(A*2402)···············
·····························································DSTLRLCVQSTHVD(DR4 od DR15)····
··································································LCVQSTHVDI(A*2402)········
········································································HVDIRTLED(A2)·······