HPV16 E6

Accession: H001747

Uniprot: Q919B8

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
PIHDIILECV CKQQLLRRE YDFAFRDLC VYRDGNPYA CDKCLKFYS ISEYRHYCY
         .         .         .         .         .         .
SVYGTTLEQQ NKPLCDLLI CINCQKPLC EEKQRHLDK QRFHNIRGR TGRCMSCCR
                                                            
SSRTRRETQL     

Epitope&Mutation

>H001747_E6
PIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
··HDIILECV(B*4002)················································································································
····IILECVYCK(A11)················································································································
········CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·················································································
············KQQLLRREVYDFAFRDLCIVYR(DP)····························································································
····················VYDFAFRDL(A*2402)·····························································································
·······················FAFRDLCIVY(B35)····························································································
·······················FAFRDLCIVY(B57)····························································································
·······················FAFRDLCIV(A*0201)··························································································
·······················FAFRDLCIV(A2)······························································································
··························RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
······························IVYRDGNPY(A3)·······················································································
······························IVYRDGNPY(A11)······················································································
································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·····································PYAVCDKCL(A*2402)············································································
·······································AVCDKCLK(A11)··············································································
··········································DKCLKFYS(A24)···········································································
··············································KFYSKISEY(A24)······································································
··············································KFYSKISEY(B62)······································································
················································YSKISEYRHY(A1)····································································
···················································ISEYRHYCY(B18)·································································
···················································ISEYRHYCY(A1)··································································
···················································ISEYRHYCY(A11)·································································
························································HYCYSVYGTTLEQQY(DR)·······················································
······························································YGTTLEQQYN(A24)·····················································
······························································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·······························································GTTLEQQYNK(A11)····················································
································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
································································TTLEQQYNK(A3)·····················································
································································TTLEQQYNK(A11)····················································
·····································································QYNKPLCDLL(A24)··············································
·····································································QYNKPLCDL(A*2402)············································
········································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
·········································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·············································································LLIRCINCQK(A11)······································
·············································································LLIRCINCQK(A3)·······································
·············································································LLIRCINCQK(A11)······································
····························································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
····························································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
····························································································EKQRHLDKKQRFHNI(DR)···················
································································································HLDKKQRFH(A3)·····················
··································································································DKKQRFHNIRGRWTG(DRB1*01)········
····································································································KQRFHNIRGR(DR*07)·············
······································································································RFHNIRGRW(A24)··············
········································································································HNIRGRWTGR(A*6801)········
············································································································GRWTGRCMSC(B27)·······
·············································································································RWTGRCMSCC(B27)······
·······················································································································SSRTRRETQL(B14)