HPV16 E6

Accession: H001738

Uniprot: B7T1G4

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MHQKRTAMFQ PQERPRKLP LCTELQTTI DIILECVYC LTGREVYAF FRDLCIVYR
         .         .         .         .         .         .
DGNPYAVCDK LKFYSKISE RHYCYSEYG TLEQQYNKP CDLLIRCIN QKPLCPEEK
         .         .         .                              
QRHLDKKQRF NIRGRWTGR MSCCRSSRT RETQL  

Epitope&Mutation

>H001738_E6
MHQKRTAMFQDPQERPRKLPQLCTELQTTIHDIILECVYCKLTGREVYAFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSEYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
······AMFQDPQER(A3)·········································································································································
······AMFQDPQER(A11)········································································································································
········FQDPQERPRK(A11)·····································································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*17)·····················································································································
··········DPQERPRKLPQLCTELQTTIHD(DP*1401)···················································································································
············QERPRKLPQL(B7)··································································································································
·················KLPQLCTEL(A*0201)··························································································································
·················KLPQLCTEL(A2)······························································································································
························ELQTTIHDIILECVY(A2)·················································································································
·························LQTTIHDII(A*0201)··················································································································
····························TIHDIILECV(A*0201)··············································································································
····························TIHDIILEC(B*4801)···············································································································
······························HDIILECV(B*4002)··············································································································
································IILECVYCK(A11)··············································································································
·················································FAFRDLCIVY(B35)····························································································
·················································FAFRDLCIVY(B57)····························································································
·················································FAFRDLCIV(A*0201)··························································································
·················································FAFRDLCIV(A2)······························································································
····················································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····································································
························································IVYRDGNPY(A3)·······················································································
························································IVYRDGNPY(A11)······················································································
··························································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
··························································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
·······························································PYAVCDKCL(A*2402)············································································
·································································AVCDKCLK(A11)··············································································
····································································DKCLKFYS(A24)···········································································
········································································KFYSKISEY(A24)······································································
········································································KFYSKISEY(B62)······································································
··········································································YSKISEYRHY(A1)····································································
·············································································ISEYRHYCY(B18)·································································
·············································································ISEYRHYCY(A1)··································································
·············································································ISEYRHYCY(A11)·································································
························································································YGTTLEQQYN(A24)·····················································
························································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······································
·························································································GTTLEQQYNK(A11)····················································
··························································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····································
··························································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··································
··························································································TTLEQQYNK(A3)·····················································
··························································································TTLEQQYNK(A11)····················································
·······························································································QYNKPLCDLL(A24)··············································
·······························································································QYNKPLCDL(A*2402)············································
··································································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
···································································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
·······································································································LLIRCINCQK(A11)······································
·······································································································LLIRCINCQK(A3)·······································
·······································································································LLIRCINCQK(A11)······································
······················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
······················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
······················································································································EKQRHLDKKQRFHNI(DR)···················
··························································································································HLDKKQRFH(A3)·····················
····························································································································DKKQRFHNIRGRWTG(DRB1*01)········
······························································································································KQRFHNIRGR(DR*07)·············
································································································································RFHNIRGRW(A24)··············
··································································································································HNIRGRWTGR(A*6801)········
······································································································································GRWTGRCMSC(B27)·······
·······································································································································RWTGRCMSCC(B27)······
·················································································································································SSRTRRETQL(B14)