HPV16 E6

Accession: H001731

Uniprot: C0KXM4

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SLYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .                                        
KKQRFHHIRG WTGRCMSCC S   

Epitope&Mutation

>H001731_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHHIRGRWTGRCMSCCRS
·FQDPQERPRK(A11)······························································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)··············································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)············································································································
·····QERPRKLPQL(B7)···························································································································
··········KLPQLCTEL(A*0201)···················································································································
··········KLPQLCTEL(A2)·······················································································································
·················ELQTTIHDIILECVY(A2)··········································································································
··················LQTTIHDII(A*0201)···········································································································
·····················TIHDIILECV(A*0201)·······································································································
·····················TIHDIILEC(B*4801)········································································································
·······················HDIILECV(B*4002)·······································································································
·························IILECVYCK(A11)·······································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)········································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)···················································································
·········································VYDFAFRDL(A*2402)····················································································
············································FAFRDLCIVY(B35)···················································································
············································FAFRDLCIVY(B57)···················································································
············································FAFRDLCIV(A*0201)·················································································
············································FAFRDLCIV(A2)·····················································································
···············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)···························································
···················································IVYRDGNPY(A3)··············································································
···················································IVYRDGNPY(A11)·············································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)··························································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)··························································
··························································PYAVCDKCL(A*2402)···································································
····························································AVCDKCLK(A11)·····································································
·······························································DKCLKFYSKISEYRHYCYSLYG(DP)·····················································
·······························································DKCLKFYS(A24)··································································
·································································CLKFYSKISEYRHYCYSLYGTTLEQQYNKPLCD(DP)········································
···································································KFYSKISEY(A24)·····························································
···································································KFYSKISEY(B62)·····························································
·····································································YSKISEYRHY(A1)···························································
········································································ISEYRHYCY(B18)························································
········································································ISEYRHYCY(A1)·························································
········································································ISEYRHYCY(A11)························································
··········································································EYRHYCYSL(A*2402)···················································
···············································································CYSLYGTTL(A*2402)··············································
···············································································CYSLYGTTL(A24)·················································
···················································································YGTTLEQQYN(A24)············································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)······························
····················································································GTTLEQQYNK(A11)···········································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)····························
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)·························
·····················································································TTLEQQYNK(A3)············································
·····················································································TTLEQQYNK(A11)···········································
··························································································QYNKPLCDLL(A24)·····································
··························································································QYNKPLCDL(A*2402)···································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)····················
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)······················
··································································································LLIRCINCQK(A11)·····························
··································································································LLIRCINCQK(A3)······························
··································································································LLIRCINCQK(A11)·····························
·····················································································································HLDKKQRFH(A3)············
·································································································································GRWTGRCMSC(B27)
··································································································································RWTGRCMSCC(B27)