HPV16 E6

Accession: H001693

Uniprot: M1RY98

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .                                        
KKQRFHNIRG WTGRCLSCC SSR   

Epitope&Mutation

>H001693_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCLSCCRSSR
·FQDPQERPRK(A11)································································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)················································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)··············································································································
·····QERPRKLPQL(B7)·····························································································································
··········KLPQLCTEL(A*0201)·····················································································································
··········KLPQLCTEL(A2)·························································································································
·················ELQTTIHDIILECVY(A2)············································································································
··················LQTTIHDII(A*0201)·············································································································
·····················TIHDIILECV(A*0201)·········································································································
·····················TIHDIILEC(B*4801)··········································································································
·······················HDIILECV(B*4002)·········································································································
·························IILECVYCK(A11)·········································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)··········································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)·····················································································
·········································VYDFAFRDL(A*2402)······················································································
············································FAFRDLCIVY(B35)·····················································································
············································FAFRDLCIVY(B57)·····················································································
············································FAFRDLCIV(A*0201)···················································································
············································FAFRDLCIV(A2)·······················································································
···············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)·····························································
···················································IVYRDGNPY(A3)················································································
···················································IVYRDGNPY(A11)···············································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)····························································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)····························································
··························································PYAVCDKCL(A*2402)·····································································
····························································AVCDKCLK(A11)·······································································
·······························································DKCLKFYS(A24)····································································
···································································KFYSKISEY(A24)·······························································
···································································KFYSKISEY(B62)·······························································
·····································································YSKISEYRHY(A1)·····························································
········································································ISEYRHYCY(B18)··························································
········································································ISEYRHYCY(A1)···························································
········································································ISEYRHYCY(A11)··························································
·············································································HYCYSVYGTTLEQQY(DR)················································
···················································································YGTTLEQQYN(A24)··············································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)································
····················································································GTTLEQQYNK(A11)·············································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)······························
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)···························
·····················································································TTLEQQYNK(A3)··············································
·····················································································TTLEQQYNK(A11)·············································
··························································································QYNKPLCDLL(A24)·······································
··························································································QYNKPLCDL(A*2402)·····································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)······················
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)························
··································································································LLIRCINCQK(A11)·······························
··································································································LLIRCINCQK(A3)································
··································································································LLIRCINCQK(A11)·······························
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)··
·················································································································EKQRHLDKKQRFHNI(DR)············
·····················································································································HLDKKQRFH(A3)··············
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)·
·························································································································KQRFHNIRGR(DR*07)······
···························································································································RFHNIRGRW(A24)·······
·····························································································································HNIRGRWTGR(A*6801)·