HPV16 E6

Accession: H001692

Uniprot: M1SMR8

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKLY KISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .         .                              
KKQRFHNIRG WTGRCMSCC SSRTRRVTQ GG  

Epitope&Mutation

>H001692_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKLYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRVTQLGG
·FQDPQERPRK(A11)·········································································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)·························································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)·······················································································································
·····QERPRKLPQL(B7)······································································································································
··········KLPQLCTEL(A*0201)······························································································································
··········KLPQLCTEL(A2)··································································································································
·················ELQTTIHDIILECVY(A2)·····················································································································
··················LQTTIHDII(A*0201)······················································································································
·····················TIHDIILECV(A*0201)··················································································································
·····················TIHDIILEC(B*4801)···················································································································
·······················HDIILECV(B*4002)··················································································································
·························IILECVYCK(A11)··················································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)···················································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)······························································································
·········································VYDFAFRDL(A*2402)·······························································································
············································FAFRDLCIVY(B35)······························································································
············································FAFRDLCIVY(B57)······························································································
············································FAFRDLCIV(A*0201)····························································································
············································FAFRDLCIV(A2)································································································
···················································IVYRDGNPY(A3)·························································································
···················································IVYRDGNPY(A11)························································································
··························································PYAVCDKCL(A*2402)··············································································
····························································AVCDKCLK(A11)················································································
·····································································YSKISEYRHY(A1)······································································
········································································ISEYRHYCY(B18)···································································
········································································ISEYRHYCY(A1)····································································
········································································ISEYRHYCY(A11)···································································
·············································································HYCYSVYGTTLEQQY(DR)·························································
···················································································YGTTLEQQYN(A24)·······················································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·········································
····················································································GTTLEQQYNK(A11)······················································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·······································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)····································
·····················································································TTLEQQYNK(A3)·······················································
·····················································································TTLEQQYNK(A11)······················································
··························································································QYNKPLCDLL(A24)················································
··························································································QYNKPLCDL(A*2402)··············································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·······························
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·································
··································································································LLIRCINCQK(A11)········································
··································································································LLIRCINCQK(A3)·········································
··································································································LLIRCINCQK(A11)········································
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·········
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)···········
·················································································································EKQRHLDKKQRFHNI(DR)·····················
·····················································································································HLDKKQRFH(A3)·······················
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)··········
·························································································································KQRFHNIRGR(DR*07)···············
···························································································································RFHNIRGRW(A24)················
·····························································································································HNIRGRWTGR(A*6801)··········
·································································································································GRWTGRCMSC(B27)·········
··································································································································RWTGRCMSCC(B27)········