HPV16 E6

Accession: H001662

Uniprot: C0KXL1

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPQERPR LPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFRDL IVYRDGNPY
         .         .         .         .         .         .
AVCDKCLKFY KISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD
         .         .                                        
KKQRFHNIRG WTGRCMSCC PS   

Epitope&Mutation

>H001662_E6
MFQDPQERPRKLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRPS
·FQDPQERPRK(A11)·······························································································································
···DPQERPRKLPQLCTELQTTIHD(DP*17)···············································································································
···DPQERPRKLPQLCTELQTTIHD(DP*1401)·············································································································
·····QERPRKLPQL(B7)····························································································································
··········KLPQLCTEL(A*0201)····················································································································
··········KLPQLCTEL(A2)························································································································
·················ELQTTIHDIILECVY(A2)···········································································································
··················LQTTIHDII(A*0201)············································································································
·····················TIHDIILECV(A*0201)········································································································
·····················TIHDIILEC(B*4801)·········································································································
·······················HDIILECV(B*4002)········································································································
·························IILECVYCK(A11)········································································································
·····························CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)·········································································
·································KQQLLRREVYDFAFRDLCIVYR(DP)····················································································
·········································VYDFAFRDL(A*2402)·····················································································
············································FAFRDLCIVY(B35)····················································································
············································FAFRDLCIVY(B57)····················································································
············································FAFRDLCIV(A*0201)··················································································
············································FAFRDLCIV(A2)······················································································
···············································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)····························································
···················································IVYRDGNPY(A3)···············································································
···················································IVYRDGNPY(A11)··············································································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*0101)···························································
·····················································YRDGNPYAVCDKCLKFYSKISE(DP*1401)···························································
··························································PYAVCDKCL(A*2402)····································································
····························································AVCDKCLK(A11)······································································
·······························································DKCLKFYS(A24)···································································
···································································KFYSKISEY(A24)······························································
···································································KFYSKISEY(B62)······························································
·····································································YSKISEYRHY(A1)····························································
········································································ISEYRHYCY(B18)·························································
········································································ISEYRHYCY(A1)··························································
········································································ISEYRHYCY(A11)·························································
·············································································HYCYSVYGTTLEQQY(DR)···············································
···················································································YGTTLEQQYN(A24)·············································
···················································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)·······························
····················································································GTTLEQQYNK(A11)············································
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DR15)·····························
·····················································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)··························
·····················································································TTLEQQYNK(A3)·············································
·····················································································TTLEQQYNK(A11)············································
··························································································QYNKPLCDLL(A24)······································
··························································································QYNKPLCDL(A*2402)····································
·····························································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····················
······························································································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······················
··································································································LLIRCINCQK(A11)······························
··································································································LLIRCINCQK(A3)·······························
··································································································LLIRCINCQK(A11)······························
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)
·················································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·
·················································································································EKQRHLDKKQRFHNI(DR)···········
·····················································································································HLDKKQRFH(A3)·············
·······················································································································DKKQRFHNIRGRWTG(DRB1*01)
·························································································································KQRFHNIRGR(DR*07)·····
···························································································································RFHNIRGRW(A24)······
·····························································································································HNIRGRWTGR(A*6801)
·································································································································GRWTGRCMSC(B27)
··································································································································RWTGRCMSCC(B27)