HPV16 E6

Accession: H001626

Uniprot: Q919D6

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
DLCIVYRDGN YAVCDKCLK YSKISEYRH CYSLYGTTL QQFNKPLCD LIRCINCQK
         .         .         .         .                    
PLCPEEKQRH DKKQRFHNI GRWTGRCMS CRSSRTRRE QL 

Epitope&Mutation

>H001626_E6
DLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSLYGTTLEQQFNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL
···IVYRDGNPY(A3)·······················································································
···IVYRDGNPY(A11)······················································································
·····YRDGNPYAVCDKCLKFYSKISE(DP*0101)···································································
·····YRDGNPYAVCDKCLKFYSKISE(DP*1401)···································································
··········PYAVCDKCL(A*2402)············································································
············AVCDKCLK(A11)··············································································
···············DKCLKFYSKISEYRHYCYSLYG(DP)······························································
···············DKCLKFYS(A24)···········································································
···················KFYSKISEY(A24)······································································
···················KFYSKISEY(B62)······································································
·····················YSKISEYRHY(A1)····································································
························ISEYRHYCY(B18)·································································
························ISEYRHYCY(A1)··································································
························ISEYRHYCY(A11)·································································
··························EYRHYCYSL(A*2402)····························································
·······························CYSLYGTTL(A*2402)·······················································
·······························CYSLYGTTL(A24)··························································
·············································KPLCDLLIRCINCQKPLCPEEK(DQ*06)·····························
··············································PLCDLLIRCINCQKPLCPEEKQ(DQ)·······························
··················································LLIRCINCQK(A11)······································
··················································LLIRCINCQK(A3)·······································
··················································LLIRCINCQK(A11)······································
·································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)·······
·································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)·········
·································································EKQRHLDKKQRFHNI(DR)···················
·····································································HLDKKQRFH(A3)·····················
·······································································DKKQRFHNIRGRWTG(DRB1*01)········
·········································································KQRFHNIRGR(DR*07)·············
···········································································RFHNIRGRW(A24)··············
·············································································HNIRGRWTGR(A*6801)········
·················································································GRWTGRCMSC(B27)·······
··················································································RWTGRCMSCC(B27)······
····························································································SSRTRRETQL(B14)