HPV16 E2

Accession: H001620

Uniprot: Q918T3

Protein: E2

Organism: Human papillomavirus type 16

Function

It is responsible for recognition and binding of origin of replication. It exists in two forms such as full length (transcriptional transactivator) and truncated (transcriptional repressor). The ratio of these found in the heterotrimeric complex, formed b

Sequence&Mutation

         .         .         .         .         .         .
RLNVCQDKIL HYENDSTDL DHIDYWKQM LECAIYYKA EMGFKHINH VVPTLAVSK
         .         .         .         .         .         .
NKALQAIELQ TLETIYNSQ SNEKWTLQD SLEVYLTAP GCIKKHGYT EVQFDGDIC
         .         .         .         .         .         .
NTMHYTNWKH YICEETSVT VEGQVDYYG YYVHEGIQT FVQFKDDAE YSKNKVWEV
         .         .         .         .         .         .
HAGGQVILCP SVFSSDEVS AEIIRQHLA HSAATHTKA ALGTKETQT IQRPRSEPD
         .         .         .         .         .         .
TGNPCHTNKL HRDSVDSAP LTAVNSSHK RINCNSNTT IVHLKGDAN LKCLRYRFK
         .         .         .         .         .          
KHCKLYTAVS TWHWTGHNV HKSAIVTLT DSECQREQF SQVKIPKTI VSTGF

Epitope&Mutation

>H001620_E2
RLNVCQDKILTHYENDSTDLRDHIDYWKQMRLECAIYYKAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVYLTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWKHIYICEETSVTVVEGQVDYYGIYYVHEGIQTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSDEVSSAEIIRQHLANHSAATHTKAVALGTKETQTTIQRPRSEPDTGNPCHTNKLLHRDSVDSAPILTAVNSSHKGRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVTLTYDSECQREQFLSQVKIPKTITVSTGF
······························································ALQAIELQL(A*0201)·····················································································································································································································································································
······················································································TLQDVSLEV(A*0201)·····························································································································································································································································
················································································································································································································································································································LYTAVSSTWHWTGHN(DQ6)································
·····················································································································································································································································································································SSTWHWTGHNVKHKS(DRB1*1502)·····················
···················································································································································································································································································································································FLSQVKIPKT(DR15)·