HPV16 E6

Accession: H001615

Uniprot: R4V4R0

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
RKLPQLCTEL TTIHHIILE VYCKQQLLR EVYDFAFRD CIVYRDGNP AVCDKCLKF
         .         .         .         .         .         .
YSKISEYRHY YSVYGTTLE QYNKPLCDL IRCINCQKP CPEEKQRHL KKQRFHNIR
         .                                                  
GRWTGRCMSC RSSRTR    

Epitope&Mutation

>H001615_E6
RKLPQLCTELQTTIHHIILECVYCKQQLLRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTR
·KLPQLCTEL(A*0201)·······················································································································
·KLPQLCTEL(A2)···························································································································
················IILECVYCK(A11)···········································································································
····················CVYCKQQLLRREVYDFAFRDLCIVYRDGNPYA(DP*0201)············································································
························KQQLLRREVYDFAFRDLCIVYR(DP)·······················································································
································VYDFAFRDL(A*2402)························································································
···································FAFRDLCIVY(B35)·······················································································
···································FAFRDLCIVY(B57)·······················································································
···································FAFRDLCIV(A*0201)·····················································································
···································FAFRDLCIV(A2)·························································································
······································RDLCIVYRDGNPYAVCDKCLKFYSKISEYRHY(DP)·······························································
··········································IVYRDGNPY(A3)··················································································
··········································IVYRDGNPY(A11)·················································································
············································YRDGNPYAVCDKCLKFYSKISE(DP*0101)······························································
············································YRDGNPYAVCDKCLKFYSKISE(DP*1401)······························································
·················································PYAVCDKCL(A*2402)·······································································
···················································AVCDKCLK(A11)·········································································
······················································DKCLKFYS(A24)······································································
··························································KFYSKISEY(A24)·································································
··························································KFYSKISEY(B62)·································································
····························································YSKISEYRHY(A1)·······························································
·······························································ISEYRHYCY(B18)····························································
·······························································ISEYRHYCY(A1)·····························································
·······························································ISEYRHYCY(A11)····························································
····································································HYCYSVYGTTLEQQY(DR)··················································
··········································································YGTTLEQQYN(A24)················································
··········································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)··································
···········································································GTTLEQQYNK(A11)···············································
············································································TTLEQQYNKPLCDLLIRCINCQK(DR15)································
············································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)·····························
············································································TTLEQQYNK(A3)················································
············································································TTLEQQYNK(A11)···············································
·················································································QYNKPLCDLL(A24)·········································
·················································································QYNKPLCDL(A*2402)·······································
····················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)························
·····················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)··························
·························································································LLIRCINCQK(A11)·································
·························································································LLIRCINCQK(A3)··································
·························································································LLIRCINCQK(A11)·································
········································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)··
········································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)····
········································································································EKQRHLDKKQRFHNI(DR)··············
············································································································HLDKKQRFH(A3)················
··············································································································DKKQRFHNIRGRWTG(DRB1*01)···
················································································································KQRFHNIRGR(DR*07)········
··················································································································RFHNIRGRW(A24)·········
····················································································································HNIRGRWTGR(A*6801)···
························································································································GRWTGRCMSC(B27)··
·························································································································RWTGRCMSCC(B27)·