HPV16 E6

Accession: H001614

Uniprot: R4V757

Protein: E6

Organism: Human papillomavirus type 16

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
KLPQLCTELQ TIHDIILEC YCKQQLLRR VYDFAFWDL IVYRDGNPY VCDKCLKFY
         .         .         .         .         .         .
SKISEYRHYC SVYGTTLEQ YNKPLCDLL RCINCQKPL PEEKQRHLD KQRFHNIRG
         .                                                  
RWTGRCMSCC SSRTR    

Epitope&Mutation

>H001614_E6
KLPQLCTELQTTIHDIILECVYCKQQLLRREVYDFAFWDLCIVYRDGNPYAVCDKCLKFYSKISEYRHYCYSVYGTTLEQQYNKPLCDLLIRCINCQKPLCPEEKQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTR
KLPQLCTEL(A*0201)·······················································································································
KLPQLCTEL(A2)···························································································································
·······ELQTTIHDIILECVY(A2)··············································································································
········LQTTIHDII(A*0201)···············································································································
···········TIHDIILECV(A*0201)···········································································································
···········TIHDIILEC(B*4801)············································································································
·············HDIILECV(B*4002)···········································································································
···············IILECVYCK(A11)···········································································································
·········································IVYRDGNPY(A3)··················································································
·········································IVYRDGNPY(A11)·················································································
···········································YRDGNPYAVCDKCLKFYSKISE(DP*0101)······························································
···········································YRDGNPYAVCDKCLKFYSKISE(DP*1401)······························································
················································PYAVCDKCL(A*2402)·······································································
··················································AVCDKCLK(A11)·········································································
·····················································DKCLKFYS(A24)······································································
·························································KFYSKISEY(A24)·································································
·························································KFYSKISEY(B62)·································································
···························································YSKISEYRHY(A1)·······························································
······························································ISEYRHYCY(B18)····························································
······························································ISEYRHYCY(A1)·····························································
······························································ISEYRHYCY(A11)····························································
···································································HYCYSVYGTTLEQQY(DR)··················································
·········································································YGTTLEQQYN(A24)················································
·········································································YGTTLEQQYNKPLCDLLIRCIN(DQ*05)··································
··········································································GTTLEQQYNK(A11)···············································
···········································································TTLEQQYNKPLCDLLIRCINCQK(DR15)································
···········································································TTLEQQYNKPLCDLLIRCINCQK(DP*0401)·····························
···········································································TTLEQQYNK(A3)················································
···········································································TTLEQQYNK(A11)···············································
················································································QYNKPLCDLL(A24)·········································
················································································QYNKPLCDL(A*2402)·······································
···················································································KPLCDLLIRCINCQKPLCPEEK(DQ*06)························
····················································································PLCDLLIRCINCQKPLCPEEKQ(DQ)··························
························································································LLIRCINCQK(A11)·································
························································································LLIRCINCQK(A3)··································
························································································LLIRCINCQK(A11)·································
·······································································································EKQRHLDKKQRFHNIRGRWTGR(DP*0201)··
·······································································································EKQRHLDKKQRFHNIRGRWTGR(DQ*05)····
·······································································································EKQRHLDKKQRFHNI(DR)··············
···········································································································HLDKKQRFH(A3)················
·············································································································DKKQRFHNIRGRWTG(DRB1*01)···
···············································································································KQRFHNIRGR(DR*07)········
·················································································································RFHNIRGRW(A24)·········
···················································································································HNIRGRWTGR(A*6801)···
·······················································································································GRWTGRCMSC(B27)··
························································································································RWTGRCMSCC(B27)·