HPV82 E6

Accession: H001600

NC: BAA90735.1

Uniprot: Q9IR59

Protein: E6

Organism: Human papillomavirus type 82

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFEDIRERPR LHELCEACN SMHNIQVLC YCKKELCRA VYNVAFTEL IVYRDNTPY
         .         .         .         .         .         .
AACKKCLMFY RIREYRRYS SVYGATLEA TNKSLYELL RCHRCQRPL PEEKQKVVD
         .         .         .                              
DKKRFHEIAG WTGQCANCR PPRQRSETQ