HPV18 E6

Accession: H001563

Uniprot: Q90133

Protein: E6

Organism: Human papillomavirus type 18

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .          
MARFEDPTRR YKLPDLCTE NTSLQDIEI CVYCKTVLE TEVPAVPET ESSRKT

Epitope&Mutation

>H001563_E6
MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEVPAVPETVESSRKT
············KLPDLCTEL(A*0201)····························
·······················SLQDIEITCV(A*0201)················
························LQDIEITCV(A*0201)················
··························DIEITCVYCKTVLEL(DR)············
·······························CVYCKTVLELTEVPAV(DR)······
···································KTVLELTE(A*0201)······
···································KTVLELTEV(A*0201)·····