HPV53 E6

Accession: H001448

Uniprot: Q4PZK2

Protein: E6

Organism: Human papillomavirus type 53

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MDRRLFENPQ RPRTLHQLC VVNKPLLEL LGCVFCKKA TASEVYNFA KDLRVVYRD
         .         .         .         .         .         .
GYPYGVCKFC LFYSKVRKL HYNCSVYGA LEELTKKKL DLLIRCYRC HPLTPEEKQ
         .         .         .                              
LHCEYKKRFH ISHMWTGAC TCWRHTTAT SAV