HPV73 E6

Accession: H001419

Uniprot: Q82005

Protein: E6

Organism: Human papillomavirus type 73

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MLFPNSEERP KLQALCDEV ISIHDINLD VFCQRGLYR EVYDFAFSD CIVYRKDKP
         .         .         .         .         .         .
YGVCQPCLKF SKIREYRRY QSVYGTTLE LTNKQLCNI IRCGKCQKP CPLEKQKHV
         .         .                                        
DEKKRFHQIA QWTGRCTRC RPSATVV