HPV11 E6

Accession: H001367

Uniprot: M4IQV7

Protein: E6

Organism: Human papillomavirus type 11

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MESKDASTSA SIDQLCKTF LSLHTLQIQ VFCRNALTT EIYAYAYKN KVVWRDNFP
         .         .         .         .         .         .
FAACACCLEL GKINQYRHF YAAYAPTVE ETNEDILKV IRCYLCHKP CEIEKLKHI
         .         .                                        
LGKARFIKLN QWKGRCLHC TTCMGDLLP   

Epitope&Mutation

>H001367_E6
MESKDASTSATSIDQLCKTFNLSLHTLQIQCVFCRNALTTAEIYAYAYKNLKVVWRDNFPFAACACCLELQGKINQYRHFNYAAYAPTVEEETNEDILKVLIRCYLCHKPLCEIEKLKHILGKARFIKLNNQWKGRCLHCWTTCMGDLLP
···········SIDQLCKTF(A*0201)··························································································································
··································································································KVLIRCYLC(A*0201)···································
··················································································································EKLKHILGKARFIKLN(DRB1*0102)·········