HPV59 E6

Accession: H001272
Uniprot: Q81964
Protein: E6
Organism: Human papillomavirus type 59

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

55-100
101-200
201-300
301-400
401-500
501-537
Legend:same sensemissenseinsertiondeletion
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Sequence&Mutation

         .         .         .         .         .         .     G:114
atggcacgctttgaggatcctacacaacgaccatacaaactgcctgatttgagcacaaca     C:60
M A R F E D P T Q R P Y K L P D L S T T      P:20


. . . . . .     G:174
ttgaatattcctctgcatgatattcgcatcaattgtgtgttttgcaaaggggaactgcaa     C:60
L N I P L H D I R I N C V F C K G E L Q      P:20


. . . . . .     G:234
gaaagagaggtatttgaatttgcttttaatgacttatttatagtgtatagagactgtaca     C:60
E R E V F E F A F N D L F I V Y R D C T      P:20


. . . . . .     G:294
ccgtatgcagcgtgtctgaaatgcatttcattttatgcaagagtaagagaattaagatat     C:60
P Y A A C L K C I S F Y A R V R E L R Y      P:20


. . . . . .     G:354
tatagagattccgtgtatggagaaacattagaggctgaaaccaagacaccgttacatgag     C:60
Y R D S V Y G E T L E A E T K T P L H E      P:20


. . . . . .     G:414
ctgctgatacgctgttatagatgcctaaaacctctatgtccaacagataaattaaagcat     C:60
L L I R C Y R C L K P L C P T D K L K H      P:20


. . . . . .     G:474
ataactgaaaaaagaagattccataatatagctggaatatatacaggacagtgtcgtggg     C:60
I T E K R R F H N I A G I Y T G Q C R G      P:20


. . . . . .     G:534
tgtcggacccgagcaagacacctaagacagcaacgacaagcgcgtagtgaaacactggtg     C:60
C R T R A R H L R Q Q R Q A R S E T L V      P:20


     G:537
taa      C:3
     P:0


Legend:gene mutationamino acid mutation