HPV81 E6

Accession: H001256

Uniprot: D7NSZ7

Protein: E6

Organism: Human papillomavirus type 81

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MVSTAVMSLG ANPTNLFVL KECEVDLDD QLTCIFCKK LTVGELLSF IRELKLVWR
         .         .         .         .         .         .
KNWPFGVCAA LCREAKVRE RRWQYSCFG TVEEEIGQP AQIYIRRHA YKPLTYQEK
         .         .         .                              
EYLVTGLIHF KIAGEWMGK CHCRGACMA QQR