HPV81 E6

Accession: H001244

Uniprot: D7NSY6

Protein: E6

Organism: Human papillomavirus type 81

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

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MVSTAVMSLG ANPTSLFLL KECEVDLDD QLTCIFCKK LTVGELLSF IRELNLVWR
         .         .         .         .         .         .
KNWPFGVCAA LCREAKVRE RRWQYSCFG TVEEETGQP AQIYIRCHA YKPLTYQEK
         .         .         .                              
EYLVTGLIHF KIAGEWMGK CHCRGACMA QQR