HPV91 E6

Accession: H001236

NC: AAM89130.1

Uniprot: Q8JTG8

Protein: E6

Organism: Human papillomavirus type 91

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MSKYCVRHTC PKPVAAHLT FVVISNNYY CTKGSNRKR DRKRYIYKP KKHSLWGIM
         .         .         .         .         .         .
SARSCSQNAK IFELCDQCN TLPTLQISC FCKKWLTTT VLSFAFRDL VVWRDSYPF
         .         .         .         .         .         .
AACLACLKFY KISQYRHFK AALAVTVEE TQQTVFELC RCCKCHKPL PIEKVQHIV
         .         .         .                              
QKAHFFYISN WKGYCLHCW SCMEKSRRS TMC

DETAIL

EPITOPE & MUTATION