HPV72 E6

Accession: H001139

NC: CAA63881.1

Uniprot: Q81997

Protein: E6

Organism: Human papillomavirus type 72

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MPMGLHNPTN WLLCKEIEV LEDLRITCI CKNELTTEE LAIAIKELQ VWRDNWPFG
         .         .         .         .         .         .
VCAPCLARAT VRELRYWTY GYGPTVEQE GKSLAELYI CHACCKPLS QEKEYQVQT
         .         .                                        
GIHFHKISGL TGRCCQCRG CTARWQP