HPV52 E6

Accession: H001082

Uniprot: D0QAN0

Protein: E6

Organism: Human papillomavirus type 52

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFEDPATRPR LHELCEVLE SVHEIRLQC QCKKELQRR VYKFLFTDL IVYRDNNPY
         .         .         .         .         .         .
GVCIMCLRFL KISEYRHYH SLYGKTLEE VRKPLSEIT RCIICQTPL PEEKERHVN
         .         .                                        
ANKRFHNIMG WTGRCSECW PRPVTQV