HPV52 E5

Accession: H001070

Uniprot: F8S529

Protein: E5

Organism: Human papillomavirus type 52

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MLGLFVFCFI LMAFCAVLR LLLSISVYA VLVLVLLLW SIGSPFKVF LYLLFLYFP
         .                                                  
MFCIHCHAQY AQLQ