HPV58 E6

Accession: H001021

Uniprot: C7E4M2

Protein: E6

Organism: Human papillomavirus type 58

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
QALETSVHEI LKCVECKKT QRSEVYDFV ADLRIVYRD NPFAVCKVC RLLSKISEY
         .         .         .         .         .         .
RHYNYSLYGD LEQTLKKCL EILIRCIIC KPLCPQEKK HVDLNKRFH ISGRWTGRC
                                                            
A     

Epitope&Mutation

>H001021_E6
QALETSVHEIELKCVECKKTLQRSEVYDFVFADLRIVYRDGNPFAVCKVCLRLLSKISEYRHYNYSLYGDTLEQTLKKCLNEILIRCIICQKPLCPQEKKRHVDLNKRFHNISGRWTGRCA
···············································KVCLRLLSK(A11)····························································
·············································································KCLNEILIR(A11)······························
··················································································ILIRCIICQ(A2)··························