HPV58 E6

Accession: H000964

Uniprot: G5CCZ2

Protein: E6

Organism: Human papillomavirus type 58

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
DAEEKPRTLH LCQALETSV EIELKCVEC KTLQRSEVY FVFADLRIV RDGNPFAVC
         .         .         .         .         .         .
KVCLRLLSKI EYRHYNYSP GDTLEQTLK CLNEILIRC ICQRPLCPQ KKRHVDLNK
         .                                                  
RFHNISGRWT RCAVCWRPR    

Epitope&Mutation

>H000964_E6
DAEEKPRTLHDLCQALETSVHEIELKCVECKKTLQRSEVYDFVFADLRIVYRDGNPFAVCKVCLRLLSKISEYRHYNYSPYGDTLEQTLKKCLNEILIRCIICQRPLCPQEKKRHVDLNKRFHNISGRWTGRCAVCWRPR
····························································KVCLRLLSK(A11)··································································
··························································································KCLNEILIR(A11)····································
·······························································································ILIRCIICQ(A2)································