HPV58 E6

Accession: H000924

Uniprot: G5CCZ0

Protein: E6

Organism: Human papillomavirus type 58

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
QDAEEKPRTL DLCQALETS HEIELKCVE KKTLQRSEV DFVFADLRI YRDGNPFAV
         .         .         .         .         .         .
CKVCLRLLSK TEYRHYNYS YGDTLEQTL KCLNEILIR IICQRPLCP EKKRHVDLN
         .         .                                        
KRFHNISGRW GRCAVCWRP    

Epitope&Mutation

>H000924_E6
QDAEEKPRTLHDLCQALETSVHEIELKCVECKKTLQRSEVYDFVFADLRIVYRDGNPFAVCKVCLRLLSKITEYRHYNYSLYGDTLEQTLKKCLNEILIRCIICQRPLCPQEKKRHVDLNKRFHNISGRWTGRCAVCWRPR
·····························································KVCLRLLSK(A11)··································································
···························································································KCLNEILIR(A11)····································
································································································ILIRCIICQ(A2)································