HPV83 E6

Accession: H000857

Uniprot: F5BAN5

Protein: E6

Organism: Human papillomavirus type 83

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MSGVRYPTNI LLCKDCEVD EDLRLICIY TNELTTAEV SFAWKELCI WDHELPYGA
         .         .         .         .         .         .
CAQCLRKAAK RELRHWSHS YGATVEEET TPLAQLYIR HMCLKPLCS EKEYLVQTG
         .         .                                        
DRFHKIAGQW GRCCQCRVP TAIQQQ