HPV62 E6

Accession: H000848

NC: AAR32246.1

Uniprot: Q676V2

Protein: E6

Organism: Human papillomavirus type 62

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MTAGPARPTN FLLCKEYDV LDDLHLTCI CKTDLSAGE LSFAIRELH VRRKDWPFG
         .         .         .         .         .         .
VCAACLLREI VRELRRWQH CFGITVEEE GSPLAQIYI CHACCMPLT QEKEYQVER
         .         .                                        
GVHFHKIAGV TGRYRNCRG CTARQQL