HPV31 E6

Accession: H000713

Uniprot: M4T782

Protein: E6

Organism: Human papillomavirus type 31

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

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MFKNPAERPR LHELSSALE PYDELRLNC YCKGQLTET VLDFAFTDL IVYRDDTPH
         .         .         .         .         .         .
GVCTKCLRFY KVSEFRWYR SVYGTTLEK TNKGICDLL RCITCQRPL PEEKQRHLD
         .         .                                        
KKKRFHNIGG WTGRCIACW RPGTETQV