HPV84 E6

Accession: H000706

NC: AAK09271.1

Uniprot: Q99FX3

Protein: E6

Organism: Human papillomavirus type 84

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MPNGRYHPTN FVLCQEYEV FDDLRLICI CKEELTEGE LAFAVKELL VWRYNFPHG
         .         .         .         .         .         .
VCMKCLCREA VRELRHWDY SFGPTVEEE GLPLAQINI CHACCKPLC QEKEYMVEL
         .         .                                        
QLLFHKIAGQ TGKCCNCRV CAARRQR