HPV40 E6

Accession: H000700

Uniprot: I0JV17

Protein: E6

Organism: Human papillomavirus type 40

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

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MSARCGSQAR LYELCDQCN TLPTLHIDC FCKTVLKTA VLAFAFREL VVWRDDFPH
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AACPRCLDLH KVNQYRNFR AAYAPTVEE TGLTILQVR RCCKCHKPL PVEKTNHIV
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KKTQFFKLKD WTGYCLHCW KCMEKGQRS TLC