HPV33 E6

Accession: H000656

Uniprot: A5JSZ5

Protein: E6

Organism: Human papillomavirus type 33

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDTEEKPR LHDLCQALE TIHNIELQC ECKNPLQRS VYDFAFTDL VVYREGNPF
         .         .         .         .         .         .
GICKLCLRFL KISEYRHYN SVYGHTLEQ VKKPLNEIL RCIICQRPL PQEKKRHVD
                                                            
LNKRFHNI