HPV71 E6

Accession: H000621

Uniprot: Q6EGR6

Protein: E6

Organism: Human papillomavirus type 71

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MPGSADLAMS GDAYPTNLF LCNQYDVDL DLNLTCIFC NQLTEVEVV FAYKELKVV
         .         .         .         .         .         .
WRKWFPFAAC CCLEIAGKL QLRYWQFSG ANTVELDTG PVTEQLIRC VCHKPLCSV
         .         .         .                              
EKERIITEGR FHKIAGHWR ACLQCWKPC ANNVP