HPV45 E6

Accession: H000599

Uniprot: A9XFT6

Protein: E6

Organism: Human papillomavirus type 45

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

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MARFDDPTQR YKLPDLCTE NTSLQEVSI CVYCKATLE TEVYQFAFK LFIVYRDCI
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AYAACHKCID YSRIRELRY SNSVYGETL KITNTELYN LIRCRRCQK LNPAEKRRH
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LKDKRRFHSI GQYRGQCNT CDQARQERL RRRETQV  

Epitope&Mutation

>H000599_E6
MARFDDPTQRPYKLPDLCTELNTSLQEVSIACVYCKATLERTEVYQFAFKDLFIVYRDCIAYAACHKCIDFYSRIRELRYYSNSVYGETLEKITNTELYNLLIRCRRCQKPLNPAEKRRHLKDKRRFHSIAGQYRGQCNTCCDQARQERLRRRRETQV
············KLPDLCTEL(A*0201)·································································································································
··································································KCIDFYSRI(A*0201)···········································································