HPV45 E6

Accession: H000583

Uniprot: M4H3S9

Protein: E6

Organism: Human papillomavirus type 45

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MARFDDPTQR YKLPDLCTE NTSLQDVSI CVYCKATLE TEVYQFAFK LFIVYRDCI
         .         .         .         .         .         .
AYAACHKCID YSRIRELRY SNSVYGETL KITNTELYN LIRCLRCQK LNPAEKRTH
         .         .         .                              
LKDKRRFHSI GQYRGQCNT CDQARQERL RRRETQV  

Epitope&Mutation

>H000583_E6
MARFDDPTQRPYKLPDLCTELNTSLQDVSIACVYCKATLERTEVYQFAFKDLFIVYRDCIAYAACHKCIDFYSRIRELRYYSNSVYGETLEKITNTELYNLLIRCLRCQKPLNPAEKRTHLKDKRRFHSIAGQYRGQCNTCCDQARQERLRRRRETQV
············KLPDLCTEL(A*0201)·································································································································
··································································KCIDFYSRI(A*0201)···········································································
···································································································NLLIRCLRC(A*0201)··········································