HPV87 E6

Accession: H000549

NC: CAC17712.2

Uniprot: Q9DIH7

Protein: E6

Organism: Human papillomavirus type 87

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MCNGTVMPNG YTPTNIFLL QEYEVDFDN RLLCIFCKE LTESELLAF LRELLLVWR
         .         .         .         .         .         .
FGFPYGVCLQ LFREAKKRE RHWEYSSYG TVEEETGVA ALQNIRCHA CKPLCWPEK
         .         .         .                              
EHMIHANLHF KIAGKWTGK SNCRAICMA RRL