HPV54 E6

Accession: H000538

Uniprot: Q8B5X7

Protein: E6

Organism: Human papillomavirus type 54

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MIYKIREGPK VRPKAVHIK DVENSYLGA SVTEPHTEE RTLADLCKV NIPMHSLQL
         .         .         .         .         .         .
PCAFCKRTVC ADIYAFQYK LYVVWRHGF YAACALCLE HGQINYRRH DRACLWETV
         .         .         .         .         .          
EQECGKPLEE YIRCWLCHK LCNVEKQRH DNGRRFHCV GYWKGRCLH WKP