HPV59 E5
Accession: H000493
Uniprot: Q81969
Protein: E5
Organism: Human papillomavirus type 59
Function
It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu
Sequence&Mutation
. . . . . . G:3967
atgataacccttgtatttgtgtgttgtgtttgtgtttgcttgtgtgtgtgttgcaatgtc C:60
M I T L V F V C C V C V C L C V C C N V P:20
. . . . . . G:4027
ccgcttctgcaatctgtctatatgtgtgcatatacatggttactagtatttgtgtatatt C:60
P L L Q S V Y M C A Y T W L L V F V Y I P:20
. . . . . . G:4087
gtggttatcacctcctcatatgagtgttttttactatatatattgttttttataattcca C:60
V V I T S S Y E C F L L Y I L F F I I P P:20
. . . . G:4129
ctgttactactatatgcccatgcaatactgtccatacaataa C:42
L L L L Y A H A I L S I Q P:13