HPV33 E6

Accession: H000471

Uniprot: C8CAK7

Protein: E6

Organism: Human papillomavirus type 33

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDTEEKPR LHDLCQALE TIHNIELQC ECKKPLQRS VYDFAFADL VVYREGNPF
         .         .         .         .         .         .
GICKLCLRFL KLSEYRHYN SLYGNTLEQ VNKPLNEIL RCIICQRPL PQEKKRHVD
         .         .                                        
LNKRFHNISG WAGRCAVCW SRRRETAL