HPV35 E6

Accession: H000459

Uniprot: Q4TUF9

Protein: E6

Organism: Human papillomavirus type 35

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDPAERPY LHDLCNEVE SIHEICLNC YCKQELQRS VYDFACYDL IVYREGQPY
         .         .         .         .         .         .
GVCMKCLKFY KISEYRRYR SVYGETLEK CNKQLCHLL RCITCQKPL PVEKQRHLE
         .         .                                        
EKKRFHNIGG WTGRCMSCW PTRRETEV   

Epitope&Mutation

>H000459_E6
MFQDPAERPYKLHDLCNEVEESIHEICLNCVYCKQELQRSEVYDFACYDLCIVYREGQPYGVCMKCLKFYSKISEYRRYRYSVYGETLEKQCNKQLCHLLIRCITCQKPLCPVEKQRHLEEKKRFHNIGGRWTGRCMSCWKPTRRETEV
···································································KFYSKISEY(A24)····································································
···································································KFYSKISEY(B62)····································································
·································································································································GRWTGRCMSC(B27)·····