HPV16 E5

Accession: H000328

Uniprot: Q9WGD8

Protein: E5

Organism: Human papillomavirus type 16

Function

It obstructs the growth suppression mechanisms: e.g. EGF receptor; activates mitogenic signalling pathways via transcription factors: c-Jun and c-Fos (important in ubiquitin pathway degradation of p53 complex by E6). Also inactivates p21 protein (p53 indu

Sequence&Mutation

         .         .         .         .         .         .
MTNLDTASTT LACFLLCFC LLCVCLLIR LLLSVSTYT LILLVLLLW TAASAFRCF
         .         .                                        
IVYILFVYIP FLIHTHARF IT   

Epitope&Mutation

>H000328_E5
MTNLDTASTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLILLVLLLWITAASAFRCFIVYILFVYIPLFLIHTHARFLIT
··············FLLCFCVLL(A*0201)····················································
····················VLLCVCLLI(A*0201)··············································
·············································VLLLWITAA(A*0201)·····················