HPV58 E6

Accession: H000259

Uniprot: F8S5P0

Protein: E6

Organism: Human papillomavirus type 58

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MFQDAEEKPR LHDLCQALE SVHEIELKC ECKKTLQRS VYDFTFADL IVYRDGNPF
         .         .         .         .         .         .
AVCKVCLRLL KISEYRHYN SLYGDTLEQ LKKRLEEIL RCIICQRPL PQEKKRHVD
         .         .                                        
LNKRFHNISG WTGRCAVCW PRRRQTQV   

Epitope&Mutation

>H000259_E6
MFQDAEEKPRTLHDLCQALETSVHEIELKCVECKKTLQRSEVYDFTFADLRIVYRDGNPFAVCKVCLRLLSKISEYRHYNYSLYGDTLEQTLKKRLEEILIRCIICQRPLCPQEKKRHVDLNKRFHNISGRWTGRCAVCWRPRRRQTQV
·······························································KVCLRLLSK(A11)········································································
··································································································ILIRCIICQ(A2)······································