HPV18 E6
Accession: H000200
Uniprot: Q9QNP8
Protein: E6
Organism: Human papillomavirus type 18
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . .
MARFEDPTRR YKLPDLCTE NTSLQDIEI CVYCKTVLE TEVFEFAFK LFVVYRDSI
. . . . . .
PHAACHKCID YSRIRELRH SDSVYGDTL KLTNTGLYN LIRCLRCQK LNPAEKLRH
. . .
LNEKRRFHKI GHYRGQCHS CNRARQERL RRRETQV
Epitope&Mutation
Legend:mutationepitope
>H000200_E6
MARFEDPTRRPYKLPDLCTELNTSLQDIEITCVYCKTVLELTEVFEFAFKDLFVVYRDSIPHAACHKCIDFYSRIRELRHYSDSVYGDTLEKLTNTGLYNLLIRCLRCQKPLNPAEKLRHLNEKRRFHKIAGHYRGQCHSCCNRARQERLQRRRETQV
············KLPDLCTEL(A*0201)·································································································································
·······················SLQDIEITCV(A*0201)·····················································································································
························LQDIEITCV(A*0201)·····················································································································
··························DIEITCVYCKTVLEL(DR)·················································································································
···································KTVLELTE(A*0201)···········································································································
···································KTVLELTEV(A*0201)··········································································································
·······································ELTEVFEFA(A*0201)······································································································
··········································EVFEFAFKDLFVVYR(DRB1*15)····························································································
··············································FAFKDLFVV(A*0201)·······························································································
················································FKDLFVVYRDSIPHA(DR)···························································································
··················································DLFVVYRDSIPHAACHKCIDFY(DQ*0301)·············································································
···················································LFVVYRDSIPHAACH(DR*03 and DR*16)···········································································
···················································LFVVYRDSIP(DRB1*03)························································································
···················································LFVVYRDSIP(DRB1*16)························································································
··································································KCIDFYSRI(A*0201)···········································································
······································································FYSRIRELRHYSDSVYGDTLEK(DQ*0501)·························································
···························································································KLTNTGLYNL(A*0201)·················································
································································································GLYNLLIRCLRCQKP(DR*08 and DR*16)······························
···································································································NLLIRCLRC(A*0201)··········································
········································································································CLRCQKPLNPAEKLR(DR)···································