HPV18 E7
Accession: H000197
NC: NP_040311.1
Uniprot: Q76Z96
Protein: E7
Organism: Human papillomavirus type 18
Function
E7 protein is transforming protein. It binds to pRB/p107 and promotes its complete degradation.
Mutation
590-600
601-700
701-800
801-900
901-907
Legend:same sensemissenseinsertiondeletion
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Sequence&Mutation
. . . . . . G:649
atgcatggacctaaggcaacattgcaagacattgtattgcatttagagccccaaaatgaa C:60
M H G P K A T L Q D I V L H L E P Q N E P:20
. . . . . . G:709
attccggttgaccttctatgtcacgagcaattaagcgactcagaggaagaaaacgatgaa C:60
I P V D L L C H E Q L S D S E E E N D E P:20
. . . . . . G:769
atagatggagttaatcatcaacatttaccagcccgacgagccgaaccacaacgtcacaca C:60
I D G V N H Q H L P A R R A E P Q R H T P:20
. . . . . . G:829
atgttgtgtatgtgttgtaagtgtgaagccagaattgagctagtagtagaaagctcagca C:60
M L C M C C K C E A R I E L V V E S S A P:20
. . . . . . G:889
gacgaccttcgagcattccagcagctgtttctgaacaccctgtcctttgtgtgtccgtgg C:60
D D L R A F Q Q L F L N T L S F V C P W P:20
. G:907
tgtgcatcccagcagtaa C:18
C A S Q Q P:5
Epitope&Mutation
Legend:mutationepitope
>H000197_E7
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLSDSEEENDEIDGVNHQHLPARRAEPQRHTMLCMCCKCEARIELVVESSADDLRAFQQLFLNTLSFVCPWCASQQ
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLS(DQ*0302)································································
MHGPKATLQDIVLHLEPQNEIPVDLLCHEQLS(DQ*0308)································································
MHGPKATLQDIVLHLEPQNEIP(DQ)···············································································
······TLQDIVLHL(A*0201)··················································································
····················IPVDLLCHEQLSDSEEENDEID(DQ*0302)······················································
·································SEEENDEIDGVNHQHLPARR(A*0201)············································
·····················································································FQQLFLNTL(A*0201)···
·······················································································QLFLNTLSFV(A2)····
·······················································································LFLNTLSFVCPWCASQQ(A*0201)
························································································LFLNTLSFV(A*0201)