HPV66 E6

Accession: H000169

Uniprot: Q4PZI9

Protein: E6

Organism: Human papillomavirus type 66

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MDSIFSNTQE PRSLHHLSE LQIPLLDLR SCVYCKKEL SLELYRFAC ELKLVYRNN
         .         .         .         .         .         .
WPYAVCRVCL FYSKVRKYR YKYSVYGAT EGITKKQLS LSIRCYRCQ PLTPEEKQL
         .         .         .                              
HCEHKRRFHY AYAWTGSCL CWRHTSRQA ESTV