HPV54 E6
Accession: H000084
NC: NP_043288.1
Uniprot: Q81018
Protein: E6
Organism: Human papillomavirus type 54
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGTCTGCTACTGAACCCCACACGGACCAGCCGCGTACTCTAGCTGATTTGTGCAAGGTA C:60
M S A T E P H T D Q P R T L A D L C K V P:20
. . . . . . G:221
TGCAATATTCCTATGCATAGTTTGCAACTTCCTTGTGCCTTTTGCAAGAAGACGGTGTGT C:60
C N I P M H S L Q L P C A F C K K T V C P:20
. . . . . . G:281
ACAGCAGAGATTTATGCATTTCAATATAAGGACCTATTTGTGGTGTGGAGACACGGCTTT C:60
T A E I Y A F Q Y K D L F V V W R H G F P:20
. . . . . . G:341
CCACATGCTGCATGTGCACTGTGCCTAGAACTGCACGGGCAAATAAATTATAGAAGGCAT C:60
P H A A C A L C L E L H G Q I N Y R R H P:20
. . . . . . G:401
CGCGACCGTGCGTGCCTGTGGGAAACAGTGGAACAAGAGTGTGGAAAGCCATTGGAAGAA C:60
R D R A C L W E T V E Q E C G K P L E E P:20
. . . . . . G:461
ATATTTATAAGGTGCTGGCTGTGCCATAAACCTTTGTGCAACGTGGAAAAGCAACGGCAC C:60
I F I R C W L C H K P L C N V E K Q R H P:20
. . . . . . G:521
GTAGATTACAACAGGCGATTCCACTGTGTTAGAGGCTATTGGAAGGGTAGGTGTCTACAT C:60
V D Y N R R F H C V R G Y W K G R C L H P:20
. G:536
TGCTGGAAGCCATAA C:15
C W K P P:4