HPV53 E6
Accession: H000083
NC: NP_041844.1
Uniprot: P36815
Protein: E6
Organism: Human papillomavirus type 53
Function
It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro
Sequence&Mutation
. . . . . . G:161
ATGGATCGTCAGTTATTTGAAAATACAGAAGAGCGACCACGTACATTGCACCAGCTATGT C:60
M D R Q L F E N T E E R P R T L H Q L C P:20
. . . . . . G:221
GAAGTTGTGAATAAACCATTGCTGGAGCTGCAACTTGGCTGTGTGTTCTGCAAGAAGGCA C:60
E V V N K P L L E L Q L G C V F C K K A P:20
. . . . . . G:281
TTGACAGCGTCAGAGGTATATAATTTTGCATATACAGATCTAAGAGTAGTGTATAGAGAC C:60
L T A S E V Y N F A Y T D L R V V Y R D P:20
. . . . . . G:341
GGGTATCCGTATGGAGTGTGCAAATTCTGTTTGCTATTTTATAGTAAGGTCCGAAAATTA C:60
G Y P Y G V C K F C L L F Y S K V R K L P:20
. . . . . . G:401
AGATATTACAATTGTTCAGTGTACGGGGCTAGCCTGGAAGCACTAACTAAAAAAAAGTTA C:60
R Y Y N C S V Y G A S L E A L T K K K L P:20
. . . . . . G:461
TCTGATTTATCAATAAGGTGCTACAGATGTCAACATCCGTTGACACCAGAGGAAAAACAG C:60
S D L S I R C Y R C Q H P L T P E E K Q P:20
. . . . . . G:521
TTACACTGTGACTATAAGAAACGGTTTCACAAAATTTCACATATGTGGACCGGGTCGTGC C:60
L H C D Y K K R F H K I S H M W T G S C P:20
. . . . G:566
CTGACATGCTGGAGACACACAACAGCAACTGAATCAGCAGTATAA C:45
L T C W R H T T A T E S A V P:14