HPV52 E6

Accession: H000082

NC: AEI61550.1

Uniprot: P36814

Protein: E6

Organism: Human papillomavirus type 52

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Mutation

102-200

201-300

301-400

401-500

501-548

Legend:same sensemissenseinsertiondeletion

Mutation type	Position	DESC	Disease	Reference
same sense	180	A → C	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	338	T → C	Disease: Cervical carcinoma Region : Beijing	Ref
same sense	350	G → T	hot spot Disease: Cervical carcinoma Region : Sichuan, Beijing	Ref
same sense	356	G → A	hot spot Disease: Cervical carcinoma Region : Beijing	Ref
same sense	356	A → G	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	378	A → C (K → R)	Disease: Cervical carcinoma Region : Sichuan	Ref
missense	379	A → G (K → R)	hot spot Disease: Cervical carcinoma Region : Sichuan, Beijing	Ref
same sense	404	T → C	Disease: Cervical carcinoma Region : Beijing	Ref
missense	467	C → A (N → K)	Disease: Cervical carcinoma Region : Sichuan	Ref
same sense	530	A → G	Disease: Cervical carcinoma Region : Beijing	Ref

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Sequence&Mutation

         .         .         .         .         .         .　　　　　G:161
atgtttgaggatccagcaacacgaccccggaccctgcacgaattgtgtgaggtgctggaa　　　　　C:60
 M  F  E  D  P  A  T  R  P  R  T  L  H  E  L  C  E  V  L  E 　　　　　P:20


         .         .         .         .         .         .　　　　　G:221
gaatcggtgcatgaaataaggctgcagtgtgtgcagtgcaaaaaagagctacaacgaaga　　　　　C:60
 E  S  V  H  E  I  R  L  Q  C  V  Q  C  K  K  E  L  Q  R  R 　　　　　P:20


         .         .         .         .         .         .　　　　　G:281
gaggtatacaagtttctatttacagatttacgaatagtatatagagacaataatccatat　　　　　C:60
 E  V  Y  K  F  L  F  T  D  L  R  I  V  Y  R  D  N  N  P  Y 　　　　　P:20


         .         .         .         .         .         .　　　　　G:341
ggcgtgtgtattatgtgcctacgctttttatctaagataagtgaatataggcattatcaa　　　　　C:60
 G  V  C  I  M  C  L  R  F  L  S  K  I  S  E  Y  R  H  Y  Q 　　　　　P:20


         .         .         .         .         .         .　　　　　G:401
tattcactgtatgggaaaacattagaagagagggtaaaaaaaccattaagtgaaataact　　　　　C:60
 Y  S  L  Y  G  K  T  L  E  E  R  V  K  K  P  L  S  E  I  T 　　　　　P:20


         .         .         .         .         .         .　　　　　G:461
attagatgtataatttgtcaaacgccattatgtcctgaagaaaaagaaagacatgttaat　　　　　C:60
 I  R  C  I  I  C  Q  T  P  L  C  P  E  E  K  E  R  H  V  N 　　　　　P:20


         .         .         .         .         .         .　　　　　G:521
gcaaacaagcgatttcataatattatgggtcgttggacagggcgctgttcagagtgttgg　　　　　C:60
 A  N  K  R  F  H  N  I  M  G  R  W  T  G  R  C  S  E  C  W 　　　　　P:20


         .         .                                        　　　　　G:548
agaccccgacctgtgacccaagtgtaa                                 　　　　　C:27
 R  P  R  P  V  T  Q  V                                     　　　　　P:8

Legend:gene mutationamino acid mutation

DETAIL

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