HPV44 E6

Accession: H000079

NC: AAA79457.1

Uniprot: P19710

Protein: E6

Organism: Human papillomavirus type 44

Function

It is an oncogenic protein which causes transformation of host cell by binding to p53 tumour suppressor protein. For binding, it requires E6-associated protein (E6-AP) which is involved in the ubiquitin ligase pathway. E6-AP binds ubiquitin to the p53 pro

Sequence&Mutation

         .         .         .         .         .         .
MESANASTSA SIDQLCKEC IPMHNLQIL VFCRKTLST EVYSFAYKQ YVVYRGNFP
         .         .         .         .         .         .
FAACAICLEL GKVNQFRHF YAGYAVTVE ETNKSILDV IRCYLCHKP CHVEKVRHI
         .         .                                        
LDKARFIKLQ TWKGRCFHC TSCMETILP